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目的:通过观察幕上肿瘤切除术患者肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-8、IL-10、Ig M、Ig A及Ig G的水平来探讨电针(EA)及经皮穴位电刺激(TEAS)对免疫功能的影响是否相同。方法:120例患者被随机分成3组:电针组(A组)、经皮穴位电刺激组(B组)、单纯全麻组(C组)。于麻醉前(T0)、诱导后4h(T1)、术后1d(T2)及术后2d(T3)采集外周血来检测TNF-α、IL-8、IL-10、Ig M、Ig A及Ig G的水平。结果:与T0时间点相比,A组和B组的IL-10水平于T2、T3时间点明显升高(P<0.05);A组的IL-8水平于T2、T3时间点明显升高(P<0.05);C组的Ig A水平于T1、T2、T3时间点明显降低(P<0.05)。与A组相比,B组和C组的IL-8水平于T2、T3时间点明显降低(P<0.05),Ig A水平于T1、T2时间点降低程度明显(P<0.05)。结论:EA可以减轻幕上肿瘤切除术患者免疫功能的抑制。TEAS不能减轻幕上肿瘤切除术患者免疫功能的抑制。
Objective: To investigate the effects of electroacupuncture (EA) on the levels of tumor necrosis factor-α (TNF-α), interleukin (IL) -8, IL-10, IgM, IgA and IgG in patients undergoing supratentorial tumor resection ) And transcutaneous electrical stimulation (TEAS) on the immune function of the same. Methods: One hundred and twenty patients were randomly divided into three groups: electroacupuncture group (A group), transcutaneous electroacupuncture (B group) and general anesthesia group (C group). Peripheral blood was collected before anesthesia (T0), 4h (T1), 1d (T2) and 2d after operation (T3) to detect TNF-α, IL-8, IL-10, IgM, IgA and Ig G level. Results: Compared with T0, the level of IL-10 in group A and group B was significantly increased at T2 and T3 (P <0.05). The level of IL-8 in group A was significantly increased at T2 and T3 (P <0.05). The level of IgA in group C was significantly lower at T1, T2 and T3 (P <0.05). Compared with group A, the level of IL-8 in group B and group C was significantly lower at T2 and T3 (P <0.05), and the level of IgA at T1 and T2 decreased significantly (P <0.05). Conclusion: EA can reduce the inhibition of immune function in supratentorial tumor resection. TEAS can not reduce the inhibition of immune function in supratentorial tumor resection.