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血小板活化因子(platelet-activating factor,PAF)是体内一种具有多种生物活性的内源性磷脂介质,对多种组织器官具有广泛效应。PAF与脑损伤后应激性胃黏膜病变有密切关系。PAF加重脑的原发性和继发性损伤,阻碍脑微循环,加剧脑水肿,加重缺血/再灌注损伤与神经细胞凋亡；同时减少胃黏膜血流量,促进粒细胞聚集并释放炎性介质,使Ca~(2+)与氧自由基释放增加,胃酸分泌增多,导致脑损伤后应激性胃溃疡发生与加重。PAF受体拮抗药对应激性胃黏膜有保护作用并减轻损伤,改善预后且减轻其并发症。
Platelet-activating factor (PAF) is a kind of endogenous phospholipid medium with a variety of biological activities in vivo, and has a wide range of effects on various tissues and organs. PAF and brain injury after stress gastric mucosal lesions are closely related. PAF aggravates primary and secondary brain injury, impedes cerebral microcirculation, aggravates cerebral edema, aggravates ischemia / reperfusion injury and neuronal apoptosis, decreases gastric mucosal blood flow, promotes granulocyte aggregation and releases inflammatory Medium, so that Ca ~ (2+) and oxygen free radicals increased, increased gastric acid secretion, leading to stress-induced gastric ulcer after the occurrence and aggravation. PAF receptor antagonists have protective effects on stress gastric mucosa and reduce injury, improve prognosis and reduce its complications.