论文部分内容阅读
目的:观察原发性高血压(EH)患者血尿酸浓度的变化及其与高血压分期的关系。方法:分别测定57例EH(EH组)患者与58例正常血压健康者(对照组)的血尿酸浓度,以血尿酸、高血压病程、TOD程度、性别进行多变量分析。结果:①EH组平均血尿酸水平较对照组明显增高[(324.7±100.61)∶(264.52±98.62)μmol/L,t=3.239,P<0.01];②EH组血尿酸增高者多于对照组(12/57,21.1%∶3/58,5.2%,χ2=6.671,P<0.01);③在EH组中伴TOD的Ⅱ、Ⅲ期EH患者血尿酸水平高于不伴TOD者[(334.19±86.15)、(384.64±94.03)∶(276.53±77.54)μmol/L];④相关分析显示血尿酸水平与高血压分期正相关(r=0.565),而与性别、年龄、血压水平及高血压病程无明显相关性。结论:血尿酸浓度增高多见于EH患者且与高血压分期相关。
Objective: To observe the change of serum uric acid concentration in patients with essential hypertension (EH) and its relationship with hypertension stage. Methods: Serum uric acid concentrations were measured in 57 EH patients and 58 healthy controls (control group). Multivariate analysis was performed on serum uric acid, duration of hypertension, TOD, and sex. Results: ① The mean serum uric acid level in the EH group was significantly higher than that in the control group [(324.7 ± 100.61) vs (264.52 ± 98.62) μmol / L, t = 3.239, P <0.01] /57,21.1%:3/58,5.2%, χ2 = 6.671, P <0.01) .③The levels of serum uric acid in patients with stage II and stage III EH with EH were higher than those without TOD [(334.19 ± 86.15 ), (384.64 ± 94.03): (276.53 ± 77.54) μmol / L] .④The correlation analysis showed that the serum uric acid level was positively correlated with the stage of hypertension (r = 0.565), but not with the gender, age, blood pressure and duration of hypertension Clearly relevant. Conclusion: The increase of serum uric acid concentration is more common in patients with EH and is related to the stage of hypertension.