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目的：测定IL-6和IL-8变应原诱导的鼻粘膜晚期反应标本中mRNA的表达。方法：采用原位杂交技术，测定变应原诱导的10例变态反应性鼻炎病人的鼻粘膜标本表达IL-6和IL-8mRNA阳性细胞数。结果：在10例标本中，2种细胞因子的阳性表达率分别为9/10和10/10。与对照相比，变应原诱导的鼻粘膜标本表达IL-6和IL-8mRNA阳性细胞数明显增加(P＜0.05和P＜0.01)。结论：IL-6和IL-8mRNA表达增加可作为变态反应性鼻炎晚期的标志。“,”Objective:To detect mRNA expression of IL-6 and IL-8 in allergen-induced late-phase cutaneous reactions in schneiderian membrane subjects. Methods:Cryostat sections from rhinitis biopsies from 24 h allergen-induced late-phase cutaneous reactions (LPR) in 10human atopic subjects were hybridization with 35S-labeled RNA probes for IL-6 and IL-8.Results:mRNA was detected for IL-6 (9/10) and IL8 (10/10).Compared with the control, there were significant increases in the numbers of ce11 expreasing mRNA expression for IL-6 and IL-8(P＜0.05, P＜0.01). Conclusion: The augmentation of mRNA expression of IL-6 and IL-8 maybe regarded as the mark of rhinits in IL PR.