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目的探讨替吉奥联合放疗治疗老年晚期胃癌的临床疗效。方法选取福建医科大学附属闽东医院2015年2月—2016年2月收治的晚期胃癌老年患者48例,随机将患者分为对照组与试验组,各24例。对照组患者采用三维适行放疗治疗,试验组在三维适形放疗基础上联合替吉奥口服治疗,两组患者均以2周为1个疗程,化疗2个疗程。比较两组患者临床疗效、毒副作用及生存情况。结果试验组患者治疗总有效率为70.8%,高于对照组的41.7%(P<0.05)。两组患者胃肠道反应、骨髓抑制、口腔黏膜炎发生率比较,差异无统计学意义(P>0.05)。试验组生存率高于对照组(P<0.05)。结论在三维适形放疗基础上联合替吉奥治疗晚期老年胃癌安全有效,患者耐受性好,可有效缩小瘤体体积和改善患者的临床症状。
Objective To investigate the clinical efficacy of TIGO combined with radiotherapy in the treatment of elderly patients with advanced gastric cancer. Methods Forty-eight elderly patients with advanced gastric cancer admitted to Fujian Mindong Hospital affiliated to Fujian Medical University from February 2015 to February 2016 were randomly divided into control group and experimental group, with 24 cases in each group. Patients in the control group were treated with three-dimensional appropriate radiotherapy. The experimental group was treated with three-dimensional conformal radiotherapy on behalf of Gio Orally. Both groups were given 2 courses of chemotherapy for 2 weeks and 2 courses of chemotherapy. The clinical efficacy, side effects and survival of the two groups were compared. Results The total effective rate of treatment group was 70.8%, higher than 41.7% of control group (P <0.05). The gastrointestinal reactions, myelosuppression and the incidence of oral mucositis in the two groups had no significant difference (P> 0.05). The survival rate of experimental group was higher than that of control group (P <0.05). Conclusion The combination of three-dimensional conformal radiotherapy and treatment of advanced gastric cancer for the treatment of advanced gastric cancer is safe and effective, patients are well tolerated, which can effectively reduce the tumor volume and improve the clinical symptoms of patients.