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目的:观察颈交感神经阻滞(CSB)对严重烧伤大鼠的救治作用,并对其可能机制进行初步探讨。方法:将大鼠随机分为正常对照组、烧伤组和CSB组,烧伤组与CSB组均制作20%体表面积Ⅲ0烧伤模型,CSB组于致伤后进行颈交感神经阻滞,观察动脉血压和心率变化;测定大鼠血中皮质酮、肾上腺素浓度;观察伤后21天动物伤死情况。结果:1.颈交感神经对严重烧伤大鼠救治效果显著,烧伤组和CSB组动物21天死亡率分别为73.33%和53.33%;2.创伤后大鼠血浆内肾上腺素浓度在伤后24小时有明显上升,然后迅速下降,但是CSB组肾上腺素浓度上升幅度远远低于烧伤组;3.与正常组相比,烧伤后血清GC的水平升高非常显著,CSB治疗组虽较正常组也升高,但显著低于烧伤组。结论:颈交感神经阻滞对严重创伤动物具有明显保护效应,其保护作用机制可能与调节创伤后神经-内分泌-免疫系统功能紊乱有关。
Objective: To observe the therapeutic effect of cervical sympathetic nerve block (CSB) on rats with severe burn and to explore its possible mechanism. Methods: The rats were randomly divided into normal control group, burn group and CSB group. Burns group and CSB group were given 20% body surface area Ⅲ 0 burns model. CSB group was subjected to cervical sympathectomy after injury and arterial blood pressure Changes in heart rate; Determination of blood corticosterone, adrenaline concentration; observed 21 days after injury, animal injuries. The cervical sympathectomy was effective in the treatment of severe burns in rats. The 21-day mortality rates in burn group and CSB group were 73.33% and 53.33%, respectively. 2. The plasma concentration of epinephrine in traumatized rats was The level of epinephrine in CSB group was much lower than that in burn group.3. Compared with normal group, the level of serum GC in burn group was significantly increased, while that in CSB group was higher than that in normal group Increased, but significantly lower than the burn group. CONCLUSION: Cervical sympathetic nerve block has a significant protective effect on severe traumatic animals, and its protective mechanism may be related to the regulation of neuro-endocrine-immune system dysfunction after trauma.