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目的：观察肝病发生过程中SE－S（sinusoidalendothelium－speCific）JLk的表达及其与血管表型的关系，以及细胞外基质的作用。方法：利用化学外均利诱导的实验。降大鼠肝右组织进行组织学及免疾组织化学研究。结果：癌性肝窦不表达SE－S抗原；而表达第八因子相关抗原（FⅧRAg）；细胞外基质过度表达且分有异常；基底膜沿着癌性肝窦形成。结论：肝癌形成过程中，发生了与细胞外基质沉积相徉的窦的毛细血管化，导致SE－S抗原的表达丧失。
OBJECTIVE: To observe the expression of SE-S (sinusoidalendothelium-speCific) JLk and its relationship with vascular phenotype and the role of extracellular matrix during the development of liver disease. METHODS: Experiments using chemical external averaging were induced. The right hepatic tissue of rats was removed for histological and immunohistochemical studies. Results: The cancerous hepatic sinus did not express SE-S antigen, but expressed the eighth factor-associated antigen (FVIIIRAg); extracellular matrix was overexpressed and abnormal; basement membrane formed along the cancerous hepatic sinusoid. Conclusion: In the process of liver cancer formation, capillarization of the sinuses, which is contrary to the deposition of extracellular matrix, occurs, leading to the loss of expression of SE-S antigen.