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目的探讨中度高海拔地区人群叶酸营养水平与炎症水平的关系。方法纳入2015年4月—12月来自云南省中度高海拔(海拔1 000~2 000 m地区的健康人群485例为研究对象,进行问卷调查、体格检查,同时进行血常规、血清炎症因子,包括hs-CRP、TNF-α、IL-1β、IL-6,血脂四项以及血清叶酸检测,按照血清叶酸浓度分为高、低血清叶酸组,分析其和炎症因子之间的关联性。结果中度高海拔地区人群中,血清叶酸浓度高者IL-1β水平较低血清叶酸组低,差异具有统计学意义(P<0.001);而两组间的血脂及其他指标的差异无统计学意义(P>0.05);血清叶酸浓度与hs-CRP、IL-1β、IL-6呈负相关关系(r_s=-0.111、-0.252、-0.119,P<0.05),与TNF-α无相关关系。结论中度高海拔地区人群的血清叶酸浓度与炎症指标明显相关,血清叶酸浓度高者其炎症指标IL-1β较低,提示良好的叶酸营养状况有助于改善中度高海拔地区人群的慢性炎症水平,促进人群健康。
Objective To explore the relationship between folic acid nutrition level and inflammation level in moderate high altitude area. Methods A total of 485 healthy subjects from Yunnan Province at a moderate altitude (from 1 000 to 2 000 m above sea level) were enrolled in this study from April 2015 to December 2015. Subjects were investigated by questionnaires and physical examinations. Blood routine, serum inflammatory cytokines, Including serum hs-CRP, TNF-α, IL-1β, IL-6, serum lipids and serum folic acid, and divided into high and low serum folic acid group according to serum folic acid concentration.The correlation between inflammatory cytokines and inflammatory cytokines was analyzed.Results Among the moderate high altitude population, the high level of serum folate and the lower level of serum IL-1β in the serum folate group were statistically significant (P <0.001); however, there was no significant difference between the two groups in the level of serum lipids and other indicators (P> 0.05). There was a negative correlation between serum folate concentration and hs-CRP, IL-1β and IL-6 (r_s = -0.111, -0.252, -0.119, P <0.05) Conclusions Serum folic acid concentration is positively correlated with inflammation index in people with moderate high altitude. High serum folic acid concentration has lower IL-1β, suggesting that good folic acid nutritional status may help to improve chronic inflammation in people with moderate and high altitude Level, to promote population health.