论文部分内容阅读
Prostate cancer (PCa) is the most frequently diagnosed malignancy and the sec-ond leading cause of cancer-related deaths in American males with similar trendsin many western countries.The existing treatment approaches and surgical inter-vention have not been able to effectively cope with this dreaded disease.Forthese reasons,it is necessary to intensify our efforts for a better understanding ofthe disease process and for the development of novel approaches for its preven-tion and treatment.Based on considerable evidence from in vivo and in vitro dataand epidemiological studies,in recent years the beverage tea has gained consid-erable attention for reducing the risk of several cancers.Much of the cancerpreventive effects of tea,especially green tea appear to be mediated by the polyphe-nols present therein.Geographical evidence suggests that the incidence andoccurrence of PCa is lower in populations that consume tea regularly.This evi-dence suggests that tea polyphenols could be extrapolated to optimize theirchemopreventive properties against PCa.PCa represents an excellent candidatedisease for chemoprevention because it is typically diagnosed in men over 50years of age and therefore,even a modest delay in neoplastic development achievedthrough pharmacological or nutritional intervention could result in a substantialreduction in the incidence of clinically detectable disease.In this review weaddress the issue of possible use of tea,especially green tea,for the prevention aswell as treatment of PCa.
Prostate cancer (PCa) is the most frequently diagnosed malignancy and the sec-ond leading cause of cancer-related deaths in American males with similar trends in many western countries. The existing treatment approaches and surgical inter -vention have not been able to effectively cope with this dreaded disease. Forthese reasons, it is necessary to intensify our efforts for a better understanding of the disease process and for the development of novel approaches for its preven- tion and treatment. Based on evidence evidence from in vivo and in vitro data and epidemiological studies, Much of the cancer preventive effects of tea, especially green tea appear to be mediated by the polyphe-nols present therein. Geographical evidence suggests that the incidence andoccurrence of PCa is lower in populations that consume tea regularly. This evi-dence suggests that tea polyphenols could be extrapol ated to optimize theirchemopreventive properties against PCa.PCarepresents an excellent candidatedisease for chemopreventioning because it is typically diagnosed in men over 50years of age and therefore, even a modest delay in neoplastic development achievedthrough pharmacological or nutritional intervention could result in a substantial reduction in the incidence of clinically detectable disease. in this review weaddress the issue of possible use of tea, especially green tea, for the prevention aswell as treatment of PCa.