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采用透明质酸为原料,以己二酰肼为交联剂、EDCI为催化剂,制备了透明质酸纳米粒,并用做抗肿瘤药物替加氟的载体。红外光谱法确定了透明质酸纳米粒官能团的变化反应。采用激光粒度测定仪测定了纳米粒的粒径和zeta电位。结果表明,本方法制备的透明质酸纳米粒的平均粒径为218.3±41.38 nm,zeta电位为-24.0±7.48 m V。替加氟在透明质酸纳米粒的包封率为92.1%。
Using hyaluronic acid as raw material, adipic hydrazide as cross-linking agent and EDCI as catalyst, hyaluronic acid nanoparticles were prepared and used as a carrier of anticancer drug tegafur. The change reaction of functional groups of hyaluronic acid nanoparticles was confirmed by infrared spectroscopy. The particle size and zeta potential of the nanoparticles were measured by laser particle sizer. The results showed that the average diameter of hyaluronic acid nanoparticles prepared by this method was 218.3 ± 41.38 nm and zeta potential was -24.0 ± 7.48 mV. The entrapment efficiency of tegafur in hyaluronic acid nanoparticles was 92.1%.