论文部分内容阅读
The new title compound 8-((4-((2,3-diaminopyridin-4-yl)-oxy)-3-fluorophenyl)-amino)-2-(4-fluorophenyl)-3-methyl-2,7-naphthyridin-1(2H)-one(C26H20F2N6O2, Mr = 486.48) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21/c with a = 15.365(3), b = 13.144(2), c = 11.863(2), β= 108.882(3)°, Z = 4, V = 2267.0(7)3, Dc = 1.425 g/cm3, F(000) = 1008, μ = 0.105 mm-1, MoKa radiation(λ = 0.71073), R = 0.0480 and wR = 0.1294 for 3197 observed reflections with I > 2σ(I). X-ray diffraction analysis reveals that the region C(substituents of 8-amino group and 3-methyl group on the 2,7-naphthyridin-1(2H)-one ring) of compound 6 are effectively planar. Intramolecular and intermolecular hydrogen bonds together with π···π interations are found in the structure. In addition, compound 6 shows potent c-Met and c-Kit kinase inhibition activities.
The new title compound 8 - ((2,3-diaminopyridin-4-yl) -oxy) -3-fluorophenyl) naphthyridin-1 (2H) -one (C26H20F2N6O2, Mr = 486.48) has been prepared and determined by single-crystal X-ray diffraction. The crystal is of monoclinic, space group P21 / c with a = 15.365 (3), b = 13.144 (2), c = 11.863 (2) β, β = 108.882 (3) °, Z = 4, V = 2267.0 73, Dc = 1.425 g / cm3, F (000) = 1008, 0.105 mm-1, MoKa radiation (λ = 0.71073), R = 0.0480 and wR = 0.1294 for 3197 observed reflections with I> 2σ (I). X-ray diffraction analysis reveals that the region C (substituents of 8- and 3-methyl group on the 2,7-naphthyridin-1 (2H) -one ring) of compound 6 are effectively planar. Intramolecular and intermolecular hydrogen bonds together with π · π interations are found in the structure. compound 6 shows potent c-Met and c-Kit kinase inhibition activities.