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将磷酸咯萘啶1.2g与磺胺多辛1.0g.伯喹45mg伍用,在抗氯喹恶性疟流行区治疗恶性疟48例,治疗后平均退热时间32±16h,平均原虫无性体转阴时间59±20.8h.服药后48h疟原虫无性体下降率为88～100％,即时疗效与单用磷酸咯萘啶1.2g对照组相似.伍用组一个月内复燃率2.5％,服药后配子体转阴时间1～12d,并能减少配子体出现,根治效果和对配子体的作用优于单用组。三药伍用后毒副反应无明显增加,是治疗抗氯喹恶性疟的较好方案.
Nicorandil phosphate 1.2g and sulfadoxine 1.0g. Boehmeria 45mg Wu for use in the anti-chloroquine falciparum malaria endemic area in the treatment of 48 cases of falciparum, after treatment, the average antipyretic time 32 ± 16h, the average protozoan asexual negative time 59 ± 20.8h 48 hours after taking the malaria parasite reduced the rate of 88 to 100%, immediate effect and single use of pyronaridine 1.2g control group similar to the Wu group within a month the rate of relapse 2.5%, after taking gametopods Negative time 1 ~ 12d, and can reduce the appearance of gametocytes, radical effect and the effect on gametophyte is better than single use group. Three side effects after drug use no significant increase in toxicity, is the treatment of chloroquine falciparum malaria a better program.