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目的:观察并探究早期氨溴索治疗新生儿胎粪吸入综合征(Meconium Aspiration Syndrome,MAS)治疗的临床有效性与安全性。方法:选择2011年5月~2013年1月在杭州市第一人民医院新生儿科接受治疗的MAS患儿94例,按照治疗方式的不同将患儿分为观察组和对照组,每组各47例。对照组仅使用常规治疗,观察组在对照组的基础上给予氨溴索雾化吸入治疗。对两组患儿疗效进行评价,并统计氧疗时间、啰音消失时间、住院时间、使用呼吸机时间及并发症和死亡例数。结果:观察组有效率为93.6%(44/47),对照组有效率为74.5%(35/47);观察组氧疗时间、啰音消失时间、住院时间、使用呼吸机时间分别为(7.1±2.2)天、(1.8±0.2)天、(4.7±2.1)天和(3.3±1.4)天,对照组为(10.5±3.4)天、(3.7±1.1)天、(6.6±2.8)天和(5.1±1.9)天;观察组并发症发生率和死亡率分别为8.5%(4/47)和2.1%(1/47),对照组为34.0%(16/47)和10.6%(5/47)。上述比较项差异均具有统计学意义(P<0.05)。结论:早期氨溴索治疗MAS疗效显著,明显缩短氧疗时间和住院时间,且安全可靠,值得在临床上进一步推广。
Objective: To observe and explore the clinical efficacy and safety of early ambroxol in the treatment of neonatal meconium aspiration syndrome (MAS). Methods: From May 2011 to January 2013, 94 children with MAS were enrolled in Department of Neonatology, Hangzhou First People’s Hospital. According to the different treatment methods, the children were divided into observation group and control group, with 47 example. The control group only used routine treatment, the observation group was given inhalation of ambroxol inhalation on the basis of the control group. The curative effect of two groups of children was evaluated, and the time of oxygen therapy, disappearance of rales, hospitalization time, time of using ventilator and complication and number of death were counted. Results: The effective rate was 93.6% (44/47) in the observation group and 74.5% (35/47) in the control group. Oxygen therapy time, auscultation time, hospital stay time and ventilator time in the observation group were (7.1 (3.7 +/- 1.1) days, (6.6 +/- 2.8) days and (1.8 +/- 0.2) days, (4.7 +/- 2.1) days and (5.1 ± 1.9) days in the observation group. The complication rate and mortality in the observation group were 8.5% (4/47) and 2.1% (1/47) respectively, while those in the control group were 34.0% (16/47) and 10.6% 47). The above differences were statistically significant (P <0.05). Conclusion: Early ambroxol treatment of MAS significant effect, significantly shortening the oxygen therapy time and hospital stay, and safe and reliable, it is worth further promotion in the clinical.