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目的探讨进展期胃癌患者术后行恒温循环式腹腔热灌注化疗预防局部复发和转移的疗效。方法回顾性分析郑州大学附属肿瘤医院普外科2010年收治的166例行胃癌根治术(D2)的进展期胃癌患者的临床资料,其中术后行腹腔热灌注化疗加静脉辅助化疗85例(治疗组,n=85),单纯静脉辅助化疗81例(对照组,n=81)。分析患者预后情况。结果术后1年、2年及3年治疗组局部复发转移率明显低于对照组,差异均有统计学意义(P<0.05);远处转移率两组差异均无统计学意义(P>0.05)。术后1年生存率治疗组与对照组差异无统计学意义(P>0.05);术后2年及3年生存率治疗组明显高于对照组,差异有统计学意义(P<0.05)。结论进展期胃癌患者术后行恒温循环式腹腔热灌注化疗可以降低局部复发率,改善患者预后。
Objective To investigate the curative effect of thermo-thermic circulating intraperitoneal hyperthermic chemotherapy on preventing local recurrence and metastasis in patients with advanced gastric cancer. Methods The clinical data of 166 patients with advanced gastric cancer treated with radical gastrectomy (D2) who underwent radical gastrectomy (D2) in Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, were retrospectively analyzed. Among them, 85 patients underwent intraperitoneal hyperthermic chemotherapy plus intravenous adjuvant chemotherapy , n = 85), simple intravenous adjuvant chemotherapy in 81 cases (control group, n = 81). Analysis of patient prognosis. Results The rates of local recurrence and metastasis in the treatment group at 1 year, 2 years and 3 years after operation were significantly lower than those in the control group (P <0.05). There was no significant difference in the distant metastasis rate between the two groups (P> 0.05). There was no significant difference in the 1-year survival rate between the treatment group and the control group (P> 0.05). The 2-year and 3-year survival rates of the treated group were significantly higher than those of the control group (P <0.05). Conclusion The patients with advanced gastric cancer undergoing constant temperature thermostat cycle intraperitoneal hyperthermic perfusion chemotherapy can reduce the local recurrence rate and improve the prognosis of patients.