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早已发现妊娠和哺乳期红细胞生成增加,但其确切机制尚不清楚。本文对胎盘催乳素治疗垂体切除后小鼠的贫血及血小板减少进行动物实验研究。用344只体重175—200g 的雌鼠,试验在控温控湿及12小时明/暗循环的实验室中进行。经咽行垂体切除术,术后置塑料笼中饲养6—7天,然后再分组试验。取5只垂体切除后的小鼠,于术后第10天开始给人胎盘催乳素(hpl)40μg/天×10天,皮下注射。第20天从尾部放血3ml,作血液学检查。第21天杀死小鼠,
It has long been found that erythropoiesis has increased during pregnancy and lactation, but the exact mechanism remains unclear. In this paper, animal studies of anemia and thrombocytopenia in mice treated with placental prolactin after pituitary resection were performed. With 344 female rats weighing 175-200 g, the experiments were performed in a laboratory with temperature and humidity control and a 12-hour light/dark cycle. The patients underwent hypophyseal pituitary resection and were placed in a plastic cage for 6-7 days after surgery, and then grouped again. Five pituitary excised mice were taken, and placental prolactin (hpl) 40 μg/day×10 days was administered on the 10th day after surgery and injected subcutaneously. On the 20th day, 3 ml of blood was drawn from the tail for hematological examination. Kill mice on day 21,