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胃肠道细胞动力学是研究胃肠道上皮细胞群体在其生存期间,在数量、形态和功储上变化规律的一门科学。正常消化道粘膜上皮不断脱落并由具有增殖能力的干细胞进行补充,这种更新的动态平衡维持了粘膜的正常结构和功能,动态平衡的破坏则将导致粘膜发生各种疾病。国外已将胃肠道细胞动力学作为胃肠道疾病的基础研究课题之一。全面的胃肠道细胞动力学研究包括测定粘膜上皮细胞总数、上皮细胞脱落数和上皮细胞增殖速率3个方面。研究概况早在19世纪初,人们就开始注意到胃肠道细胞的更新。当时的科学水平只能观察到肠腺窝和胃小窝是有高度有丝分裂活动的部位。相
Gastrointestinal cell dynamics is a science that studies the changes in the number, morphology, and work storage of the gastrointestinal epithelial cell population during its life span. The normal epithelial lining of the digestive tract continues to fall off and is replenished by proliferative stem cells. This updated dynamic balance maintains the normal structure and function of the mucous membranes. The disruption of homeostasis will lead to various diseases of the mucous membranes. In foreign countries, gastrointestinal cell dynamics has been considered as one of the basic research topics of gastrointestinal diseases. Comprehensive gastrointestinal cell dynamics studies include the determination of the total number of mucosal epithelial cells, epithelial cell shedding, and epithelial cell proliferation rate. Research Overview As early as the early 19th century, people began to notice the renewal of gastrointestinal cells. At the time of the scientific level, only the intestinal glands and the gastric pits were observed to have high mitotic activity. phase