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糖尿病患者应用胰岛素治疗,是要防止由于胰岛素不足引起的代谢异常,但也不要引起低血糖。给予最适量的胰岛素是非常重要的,但以往所应用的胰岛索多次注射疗法及胰岛素持续注射疗法都很难精确地控制血糖。在人和猴子中已证实,血中胰岛素、胰高血糖素及葡萄糖的浓度具有短周期性变化(约10～13min),这与β细胞分泌胰岛素的周期性有关。Matthews 等将这种胰岛素周期性分泌的现象应用于糖尿病的治疗,进行胰岛素间歇注射法与持续注射法的比较。Bratusch 等将血糖值维持在禁食水平,应用葡萄糖消耗量和抑制肝内葡萄糖异生量作为衡量胰岛
Insulin treatment in patients with diabetes, is to prevent metabolic disorders due to lack of insulin, but also do not cause hypoglycemia. It is important to give the optimal amount of insulin, but it has been difficult to accurately control blood sugar with multiple islet injections and continuous insulin injections in the past. It has been demonstrated in humans and monkeys that short-term changes in the blood levels of insulin, glucagon and glucose (about 10-13 min.) Are associated with the periodicity of β-cell insulin secretion. Matthews and other will be cyclical secretion of this phenomenon of insulin used in the treatment of diabetes, intermittent insulin injection and continuous injection of comparison. Bratusch and other blood glucose levels will be maintained at fasting levels, the application of glucose consumption and inhibition of intrahepatic gluconeogenesis as a measure of islets