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目的了解医院2013年至2015年阴沟肠杆菌分离株的耐药性特点,为临床合理使用抗菌药物提供参考。方法使用药敏纸片扩散法进行物敏感性试验,药敏结果判断参照CLSI 2015年标准。结果 549株阴沟肠杆菌中,菌株来源以呼吸道标本、分泌物、尿液标本为主;临床感染主要分布于急诊外科、外科、内科、重症监护病房(ICU);其对氨苄西林、头孢西丁、头孢唑林的耐药率高于90%,阿莫西林耐药率高于85%,哌拉西林、头孢哌酮的耐药率低于30%,三代头孢和喹诺酮类抗菌药物的耐药率低于55%,氨基糖苷类抗菌药物的耐药率低于35%,氨曲南的平均耐药率为38.1%。结论阴沟肠杆菌对临床常用抗菌药物的耐药率呈下降趋势;对于耐碳青霉烯类抗菌药物菌株的出现应引起重视。
Objective To understand the drug resistance characteristics of Enterobacter cloacae isolates in the hospital from 2013 to 2015 and provide references for the rational use of antibacterials in clinic. Methods Susceptibility test was carried out using drug-sensitive disk diffusion method. The drug susceptibility test was based on CLSI 2015 standard. Results Among the 549 strains of Enterobacter cloacae, the strains were mainly respiratory specimens, secretions and urine samples. The clinical infections were mainly in emergency surgery, surgery, internal medicine and intensive care unit (ICU) , Cefazolin resistance rate was higher than 90%, amoxicillin resistance rate was higher than 85%, piperacillin, cefoperazone resistance rate of less than 30%, third-generation cephalosporin and quinolone antibiotic resistance The rate of resistance to aminoglycoside antibiotics was less than 35%, while the average rate of aztreonam was 38.1%. Conclusion The resistance rates of Enterobacter cloacae to commonly used antibiotics in clinical use are declining. The occurrence of carbapenem-resistant antibacterials strains should pay more attention.