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目的：探讨最大用力呼气中段流量时间（ＦＥＴ２５％～７５％）的正常值及临床应用价值。方法：应用美国６２００ＡｕｔｏｂｏｘＤＬ型体积描记仪，测定了２０１例健康成人，３２例限制性通气障碍患者和１６８例ＣＯＰＤ患者ＦＥＴ２５％～７５％。结果：ＦＥＴ２５％～７５％与年龄显著相关（Ｐ＜０．０１），求出其预计回归方程式。对各组依实测值占预计值百分比均值进行了比较。慢支组、轻、中、重度肺气肿组ＦＥＧ２５％～７５％明显延长（Ｐ＜０．０１），ＭＭＦ、ＦＥＶ１．０／ＦＶＣ％、ＦＶＣ明显减低（Ｐ＜０．０１）；限制性疾患组ＦＥＴ２５％～７５％缩短（Ｐ＜０．０１），ＭＭＦ及ＦＶＣ明显减低（Ｐ＜０．０１），ＦＥＶ１．０／ＦＶＣ％增高。结论：ＦＥＴ２５％～７５％不仅是判断阻塞性通气障碍的一项十分有用的指标，而且其缩短也可作为限制性通气障碍的参考指标之一。
Objective: To investigate the normal value and clinical value of the maximum forced expiratory flow time (FET25% ~ 75%). METHODS: Twenty-five healthy adults, 32 patients with restrictive ventilatory disorders, and 168 patients with COPD were enrolled in this study. Twenty-five to 75% of FETs were measured using the 6200 Autobox DL plethysmograph. Results: 25% -75% of FETs were significantly related to age (P <0.01), and the expected regression equation was obtained. According to the actual value of each group accounted for the percentage of the expected average value were compared. (P <0.01), MMF, FEV1.0 / FVC% and FVC were significantly decreased in chronic bronchitis group, chronic bronchitis group, mild, moderate and severe emphysema group (P <0.01) FET25% ~ 75% shortened FET (P <0.01), MMF and FVC decreased significantly (P <0.01), FEV1.0 / FVC% increased. Conclusion: FET25% ~ 75% is not only a very useful indicator to judge obstructive ventilatory disorder, but also can be used as a reference index of restrictive ventilatory disorder.