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目的:对分析葛根素联合倍他司汀改善椎-基底动脉缺血性眩晕患者血液流变学指标的临床疗效。方法:随机将确诊椎-基底动脉缺血性眩晕患者分为2组,复方丹参组50例给予复方丹参联合低分子右旋糖酐治疗,葛根素组51例给予葛根素联合倍他司汀治疗,连续治疗7天后对比血液流变学指标、血流速度指标以及临床疗效。结果:葛根素组改善全血高切比粘度、全血低切比粘度和血浆比粘度等血液流变学指标明显优于复方丹参组,差异具有统计学意义(P<0.05);葛根素组改善基底动脉、左椎动脉和右椎动脉等血流速度指标明显优于复方丹参组,差异具有显著性统计学意义(P<0.01);葛根素组总有效率90.20%明显优于复方丹参组74.00%,差异具有统计学意义(P<0.05)。结论:葛根素联合倍他司汀治疗椎-基底动脉缺血性眩晕效果确切,能够通过影响血液流变学指标和血流速度指标改善脑微循环血流量,消除病因和环境眩晕症状,在促进患者早期康复和提高生存质量方面具有非常重要的意义。
Objective: To analyze the clinical effect of puerarin combined with betahistine on hemorheology in patients with vertebro-basilar ischemic vertigo. Methods: The patients with vertebrobasilar ischemic vertebrae were randomly divided into two groups. Fufang Danshen group (50 cases) was treated with compound Danshen combined with low molecular weight dextran. Puerarin group (51 cases) was treated with puerarin plus betahistine, and continuous treatment After 7 days, hemorheology index, blood flow velocity index and clinical effect were compared. Results: The hemorheology indexes of Puerarin group were significantly better than compound Danshen group in improving whole blood high shear viscosity, whole blood low shear viscosity and plasma specific viscosity. The difference was statistically significant (P <0.05) The improvement of basilar artery, left vertebral artery and right vertebral artery and other blood flow velocity indicators were significantly better than the compound Salvia group, the difference was statistically significant (P <0.01); puerarin group, the total efficiency of 90.20% was significantly better than the compound Salvia group 74.00%, the difference was statistically significant (P <0.05). Conclusion: Puerarin combined with Betalistine is effective in treating vertebrobasilar ischemic vertigo. It can improve blood flow of cerebral microcirculation and eliminate the etiology and environment dizziness by influencing hemorheological indexes and blood flow velocity indexes. Patients with early rehabilitation and improve the quality of life has a very important significance.