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目的:观察围手术期中西医结合治疗原发性支气管肺癌的临床效果。方法:采用随机双盲法将70例原发性支气管肺癌患者分为2组,每组35例,对照组术后给予单纯化疗治疗,观察组在对照组治疗基础上行中医辨证治疗,比较2组的临床疗效,治疗前后中医证候总积分、生存质量Karnofsky(KPS)评分,不良反应及1年、3年生存率。结果:观察组总有效率80.0%,对照组总有效率54.3%,2组比较,差异有统计学意义(P<0.05)。治疗后,观察组中医证候总积分较治疗前、对照组下降,差异均有统计学意义(P<0.05);观察组KPS评分较治疗前、对照组升高,差异均有统计学意义(P<0.05)。观察组3年生存率42.9%,对照组3年生存率20.0%,2组比较,差异有统计学意义(P<0.05)。2组患者在治疗期间均无明显不良反应发生。结论:相比单纯化疗干预,在化疗基础上联合中医辨证治疗能明显提高患者的生存质量,改善预后。
Objective: To observe the clinical effect of perioperative combination of traditional Chinese and western medicine in the treatment of primary bronchogenic carcinoma. Methods: A total of 70 patients with primary bronchogenic carcinoma of lung were divided into two groups by randomized double-blind method: 35 cases in each group. The control group was treated with chemotherapy alone. The observation group was treated with traditional Chinese medicine on the basis of the control group. The clinical curative effect, TCM syndrome total score before and after treatment, Karnofsky (KPS) quality of life, adverse reaction and 1 year and 3 year survival rate. Results: The total effective rate was 80.0% in the observation group and 54.3% in the control group. There was significant difference between the two groups (P <0.05). After treatment, the total score of TCM syndrome in the observation group was significantly lower than that in the control group and the control group (P <0.05). The KPS score in the observation group was significantly higher than that before treatment and the control group (P <0.05) P <0.05). The 3-year survival rate was 42.9% in the observation group and 3-year survival rate was 20.0% in the control group. There was significant difference between the two groups (P <0.05). No adverse reactions occurred in the two groups during the treatment. Conclusion: Compared with simple chemotherapy intervention, combined with traditional Chinese medicine based on chemotherapy can significantly improve the quality of life of patients and improve prognosis.