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目的探讨凋亡相关基因survivin在NSCLC中的表达及其与p53的关系。方法选取52例NSCLC患者组织。检测survivin及p53蛋白的表达。结果正常肺组织中survivin的阳性表达率为0.00%,NSCLC中表达率为65.39%;survivin在p53阳性表达组和阴性表达组中的表达率分别为80%和35.29%,二者比较差异有统计学意义。结论 survivin过度表达提示NSCLC预后不良;p53的失活和survivin的过度表达可能在NSCLC癌变中起协同作用。
Objective To investigate the expression of apoptosis related gene survivin in NSCLC and its relationship with p53. Methods 52 cases of NSCLC tissue were selected. Detect the expression of survivin and p53 protein. Results The positive rate of survivin in normal lung tissue was 0.00%, and the positive rate in NSCLC was 65.39%. The positive rates of survivin in the positive and negative groups were 80% and 35.29%, respectively Significance of learning. Conclusion The overexpression of survivin suggests poor prognosis of NSCLC. Inactivation of p53 and overexpression of survivin may play a synergistic role in the carcinogenesis of NSCLC.