Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult

• 作 者: Dan Lyu Ning Tang Andrew W. Wo
• 机 构: DepartmentofPainManagement,DepartmentofPsychology,ReproductiveMedicineCenter
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2020年5期
• 关键词: caspase-3 DEVELOPMENTAL neuroapoptosis hippocampus KETAMINE MORRIS water MAZE N-
• 基金项目: supported by the National Natural Science Foundation of China,No.81200851 (to DL),the National Institutes of Health of the USA,No.NS 040723 (to QL).

Ketamine exposure can lead to selective neuroapoptosis in the developing brain.p66ShcA,the cellular adapter protein expressed selectively in immature neurons,is a known pro-apoptotic molecule that triggers neuroapoptosis when activated.Sprague-Dawley rats