Gelation Mechanism of Erythromycin Ethylsuccinate During Crystallization

• 作 者: Xiandong Su Zhenguo Gao Ying Bao Miao Guan Sohrab Rohani Qiuxiang Yin Hongxun Hao Chuang Xie Jingkang Wang
• 机 构: School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China“,”Collabora
• 出 处: 天津大学学报（英文版）
• 发表日期: 2019年2期
• 关键词: Gelation Solvate Crystallization Phase diagram Molecular self-assembly

In this paper,the gelation mechanism of erythromycin ethylsuccinate (EES) during crystallization is investigated for the first time.The generated semisolid gel-like phase exhibited a 3D fibrillar network morphology and the typical rheological properties of gels.The fibers inside the gel-like phase were confirmed to be new types of EES solvates using powder X-ray diffraction,thermogravimetric analysis/differential scanning calorimetry,and gas chromatography.The gelation and crystallization regions in EES-1-propanol solid-liquid phase diagram were determined.Analyses of solvent parameters showed that moderate solvent polarity may promote EES gelation.Fourier transform infrared spectra,nuclear magnetic resonance spectra,and scanning electron microscopy analyses indicated that through intermolecular hydrogen bonds,EES and solvent molecules assembled into fibers via crystallographic mismatch branching growth.The fibers intertwined into a 3D network microstructure and formed a gel-like phase,completely immobilizing the solution.