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目的探讨Toll样受体4(TLR4)在胎膜早破中的表达及意义。方法选择100例早产胎膜早破孕妇设为PPROM组,100例足月胎膜早破孕妇设为PROM组,100例足月正常孕妇作为对照组,采用免疫组织化学法检测胎膜破裂口处胎膜组织TLRs的分布与表达。结果胎膜组织中TLR4的表达,PPROM组与PROM组比较差异无统计学意义;PROM组与对照组比较差异有统计学意义;PPROM组与对照组比较差异有统计学意义。结论 Toll样受体4在胎膜早破孕妇中高表达,为胎膜早破的早期诊断提供更敏感的信号指标。
Objective To investigate the expression and significance of Toll-like receptor 4 (TLR4) in premature rupture of membranes. Methods 100 pregnant women with preterm premature rupture of membranes were enrolled as PPROM group, 100 pregnant women with full term premature rupture of membranes as PROM group and 100 full-term pregnant women as control group. Immunohistochemistry was used to detect the location of rupture of membranes Distribution and expression of TLRs in fetal membranes. Results There was no significant difference in the expression of TLR4 between PPROM group and PROM group. The differences between PROM group and control group were statistically significant. The difference between PPROM group and control group was statistically significant. Conclusion Toll-like receptor 4 is highly expressed in pregnant women with premature rupture of membranes and provides more sensitive signal indicators for the early diagnosis of premature rupture of membranes.