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目的:观察胆石六号汤剂对胆色素结石的防治作用,并初探其作用机制。方法:40只雌性豚鼠随机分为空白对照组(n=10)、模型组(n=15)和胆石六号汤剂组(n=15)。除空白对照组外,其余2组采用饮食诱发法建立胆色素结石模型。同时胆石六号汤剂组给予胆石六号汤剂7.7 g·kg-1·d-1灌胃30 d。之后观察各组的成石率、血清胆色素含量、肝脏超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果:空白对照组仅有1只有结石发生,成石率为10%;模型组成石率为91.67%。胆石六号汤剂组成石率为26.67%,较模型组明显降低。胆石六号汤剂组血清总胆红素、直接胆红素和间接胆红素含量低于模型组(P<0.05),同时肝脏SOD活性明显高于模型组,而MDA含量明显低于模型组。结论:胆石六号汤剂可降低豚鼠胆色素结石模型成石率,其机制与其抗氧化应激有关。
Objective: To observe the prevention and treatment of gallstone 6 gallbladder decoction and to explore its mechanism. Methods: Forty female guinea pigs were randomly divided into blank control group (n = 10), model group (n = 15) and gallstone 6 decoction group (n = 15). In addition to the blank control group, the other two groups using diet-induced method to establish the model of bile pigment stones. At the same time, gallstone No. 6 decoction group was given gutase No. 6 decoction 7.7 g · kg-1 · d-1 for 30 days. The rate of stone formation, serum bilirubin content, liver SOD activity and malondialdehyde (MDA) content were observed. Results: In the control group, only 1 stone was formed, the stone formation rate was 10% and the model stone composition was 91.67%. The stone ratio of gallstone 6 decoction is 26.67%, which is obviously lower than the model group. The content of serum total bilirubin, direct bilirubin and indirect bilirubin in Ganshi No.6 decoction group was lower than that in model group (P <0.05), while the SOD activity in liver was significantly higher than that in model group, while MDA content was significantly lower than that in model group . Conclusion: Ganshi Liu decoction can reduce the rate of stone formation in the model of biliary pigment stones in guinea pigs, and its mechanism is related to its anti-oxidative stress.