论文部分内容阅读
目的探讨中国在消灭脊髓灰质炎(脊灰)后期的免疫策略。方法运用循证医学的方法,检索国内外研究资料,调查中国脊灰疫苗生产和使用现状,从免疫策略比较赛宾株-脊灰灭活疫苗(Sabin-Inactivated Poliovirus Vac-cine,sIPV)替代口服脊灰减毒活疫苗(Oral Poliomyelitis Live Vaccine,OPV)的可行性,并从免疫程序等方面进行前瞻性综合分析。结果中国应考虑选择以IPV替代OPV的免疫策略,且国产sIPV即将问世,在政策、技术、疫苗供应和其它保障方面均具备了替代的条件,常规免疫可参照目前OPV免疫程序。结论中国应进一步加强消灭脊灰后期免疫策略的研究,积极做好sIPV替代OPV的准备工作。
Objective To explore the immunization strategy of China in eradicating poliomyelitis (polio). Methods The evidence-based medicine was used to search the domestic and foreign research data to investigate the status quo of poliovirus production and use in China. The immunization strategy was compared with Sabin-Inactivated Poliovirus Vaccine (sIPV) The feasibility of Oral Poliomyelitis Live Vaccine (OPV) was prospectively analyzed from aspects of immune procedure and so on. Results China should consider selecting an immunization strategy that replaces OPV with IPV and the forthcoming domestic sIPV will come out with alternative conditions in terms of policies, technologies, vaccine supply and other safeguards. Conventional immunization may refer to the current OPV immunization program. Conclusion China should further strengthen the research on eliminating post-polio immunization strategies and actively prepare for the replacement of OPV by sIPV.