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对我院852名职工进行HBsAg检测,发现HBsAg阳性者59例,总检出率6.9％。各组HBsAg阳性率分别为:工人组11％,医护组6.7％,血液接触组6.7％,职员组4.1％,医技组3.9％。HBsAg的RPHA滴度≤64~×者17例中无1例HBeAg阳性者,而HBsAg滴度>64~×者42例中HBeAg阳性者11例(26.2％)。HBsAg携带者中HBeAg阳性者的SGPT异常率(36.4％)显著高于HBeAg阴性者(18.8％)。59例携带者中1年后HBsAg阴转者4例,2年后阴转者9例,年平均自然阴转率11％。HBsAg持续携带者中转变为慢性迁延性肝炎者16例(34.8％)慢性活动性肝炎1例。
852 workers in our hospital for HBsAg testing found that 59 cases of HBsAg-positive, the total detection rate of 6.9%. The positive rate of HBsAg in each group was 11% in workers group, 6.7% in health care group, 6.7% in blood exposure group, 4.1% in staff group and 3.9% in medical technology group. There were no HBeAg positive cases in 17 cases of HBsAg with RPHA titer≤64 ~ ×, HBeAg titer> 64 ~ × in 42 cases, HBeAg positive in 11 cases (26.2%). The abnormal rate of SGPT in HBeAg-positive patients (36.4%) was significantly higher than that in HBeAg-negative patients (18.8%). Among the 59 carriers, 4 were HBsAg-negative one year later, 9 negative-metastasis two years later, and the average annual natural conversion rate was 11%. Sixteen patients (34.8%) with chronic active hepatitis were converted to chronic persistent hepatitis in HBsAg carriers.