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目的 观察依那普利和硝苯地平控释片对早期糖尿病肾病合并高血压患者血压及尿白蛋白排泄率 (UAER)的影响。方法 随机将 44例病人分为 2组 :依那普利组 (10 mg,2次 /d,2 2例 ) ;硝苯地平控释片组 (30 mg,1次 /d,2 2例 )。疗程 6个月 ,观察治疗前后血压及 UAER的变化。结果 两组治疗后均能明显降低血压 (P <0 .0 1)及 UAER,由 90 .2和 86 .0分别降至 6 7.4和70 .8,下降 2 9.1%和 2 3.5 % ,P值均 <0 .0 1,但两组比较差异无显著性 (P>0 .0 5 )。两组治疗后U AER下降幅度与收缩压、舒张压下降幅度之间比较无显著相关性 (P值均 >0 .0 5 )。结论 依那普利和硝苯地平控释片均能有效降低血压 ,减少尿蛋白的排泄 ,保护肾脏功能
Objective To observe the effects of enalapril and nifedipine controlled release tablets on blood pressure and urinary albumin excretion rate (UAER) in patients with early diabetic nephropathy complicated with hypertension. Methods Forty-four patients were randomly divided into 2 groups: enalapril group (n = 10), nifedipine controlled release group (30 mg once a day, n = 22) . Course of 6 months, observed before and after treatment of blood pressure and UAER changes. Results After treatment, the blood pressure (P <0.01) and UAER in both groups were significantly decreased from 90.2 and 86.0 to 6 7.4 and 70.8 respectively, down 21.9% and 23.5% respectively, P value All <0. 01, but there was no significant difference between the two groups (P> 0.05). There was no significant correlation between the decrease of U AER and the decrease of systolic pressure and diastolic pressure after treatment (P> 0.05). Conclusion Both enalapril and nifedipine controlled release tablets can effectively reduce blood pressure, reduce urinary protein excretion and protect renal function