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骨桥蛋白(OPN)是一种分泌型磷酸化糖蛋白,与其主要受体整合素和CD44相互作用,参与细胞信号转导,并在肿瘤细胞的黏附、浸润、迁移及新生血管形成过程中起关键作用。组织和血液中的OPN表达量也是肿瘤诊断和预后的指标。近年来,很多研究发现OPN在乳腺癌和卵巢癌的复发和转移过程中发挥重要作用,作为一个很好的肿瘤转移标志物,OPN是诊断与治疗肿瘤的新靶点。在此结合OPN的一般生物学特点,就近年来OPN与结直肠癌的诊断、预后、转移和治疗的相关性研究展开综述。
Osteopontin (OPN) is a secreted phosphorylated glycoprotein that interacts with its major receptor integrin and CD44 and participates in cell signaling and plays an important role in the adhesion, invasion, migration and neovascularization of tumor cells Key role. OPN expression levels in tissues and blood are also indicators of tumor diagnosis and prognosis. In recent years, many studies have found that OPN plays an important role in the recurrence and metastasis of breast and ovarian cancer. As a good marker of tumor metastasis, OPN is a new target for diagnosis and treatment of cancer. Combined with the general biological characteristics of OPN, this review summarizes the correlation between OPN and the diagnosis, prognosis, metastasis and treatment of colorectal cancer in recent years.