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目的比较胰岛素泵(CSII)和多次皮下胰岛素注射(MSII)对合并冠心病的2型糖尿病患者脂代谢改善的差异。方法合并冠心病的2型糖尿病住院患者80例随机分为2组,CSII组40例采用胰岛素泵连续皮下注射短效胰岛素;MSII组患者40例采用多次皮下胰岛素注射法,在每日3餐前注射短效胰岛素,并在每晚睡前加用超长效胰岛素。结果 CSII组和MSII组治疗后,血清甘油三酯、低密度脂蛋白胆固醇水平均明显下降,高密度脂蛋白胆固醇水平均明显上升,但CSII组治疗后3项指标的改善较MSII组更明显,差异有统计学意义(P均<0.05)。结论 CSII能更迅速、更有效地改善合并冠心病的2型糖尿病患者的脂质代谢水平。
Objective To compare the improvement of lipid metabolism in patients with type 2 diabetes mellitus with coronary heart disease by insulin pump (CSII) and multiple subcutaneous insulin injections (MSII). Methods Eighty hospitalized patients with type 2 diabetes mellitus with coronary heart disease were randomly divided into two groups. Forty patients in CSII group were injected subcutaneous insulin short-acting insulin by insulin pump. Forty patients in MSII group received multiple subcutaneous insulin injections. Short-acting injection of insulin before, and every night before going to bed with long-acting insulin. Results After treatment, the levels of serum triglyceride and low density lipoprotein cholesterol were significantly decreased and the levels of high density lipoprotein cholesterol were significantly increased in CSII group and MSII group. However, the improvement of 3 indexes in CSII group was more obvious than that in MSII group. The difference was statistically significant (P <0.05). Conclusion CSII can improve the lipid metabolism of type 2 diabetes mellitus patients with coronary heart disease more quickly and more effectively.