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Objective: To investigate the relationship between P-glycoprotein (P-gp) and adhesion molecule CD44 expression as well as their clinical significance in esophageal carcinoma. Methods: To examine the expressed level of P-gp and CD44 by flow cytometry (FCM) in the operated samples of 70 cases with esophageal carcinoma and their normal mucosa of esophageal incision, and to evaluate their relationship with clinicopathological factors. Results: Among the 70 cases with esophageal car- cinoma, the expression of P-gp in the 27 cases (38.6%) was negative (positive cells <25%); 11 cases (15.7%) were 25%–40% expression of P-gp positive cells; 14 cases (20%) were 41%–60% expression of P-gp positive cells; 18 cases (25.7%) were the high expression (positive cells >60%) of P-gp. Of the cases with the tumor sizes being more than 4 cm, the expression of CD44 showed a significant difference (P<0.05) in 25 cases with P-gp positive, compared with 19 cases with P-gp negative. Of the cases with high-mild differentiated esophageal carcinoma, the expression of CD44 showed a significant difference (P<0.05) in 22 cases with P-gp positive, compared with 17 cases with P-gp negative. Of the cases with clinical III--IV stage, the expression of CD44 showed a significant difference (P<0.05) in 26 cases with P-gp positive, compared with 10 cases with P-gp negative. Of the cases with lymph node metastasis, the CD44 expression showed a significant difference (P=0.050) in 27 cases with P-gp positive, compared with 11 cases with P-gp negative. Of the cases of the patients’ age being more than 56 years, the expression of CD44 showed a significant difference (P<0.01) in 27 cases with P-gp positive, compared with 12 cases with P-gp negative. When the P-gp and CD44 expression were positive, the clinical II stage and III–IV stage in esophageal carcinoma was showed a significant difference (P<0.05). Conclusion: When the CD44 and P-gp both have the positive high expression, it will be signifi- cantly associated with the esophageal carcinoma progression and metastasis, so both were a positive expression in esophageal carcinoma, it might suggest a poor and unfavorable prognosis result.
Objective: To investigate the relationship between P-gp and CD44 by flow cytometry (FCM) in the operated samples of 70 cases with esophageal carcinoma and their normal mucosa of esophageal incision, and to evaluate their relationship with clinicopathological factors. Results: Among the 70 cases with esophageal car- cinoma, the expression of P-gp in the 27 cases (38.6 11 cases (15.7%) were 25% -40% expression of P-gp positive cells; 14 cases (20%) were 41% -60% expression of P-gp positive Of the cases with the tumor sizes being more than 4 cm, the expression of CD44 showed a significant difference (P <0.05). Of the 18 cases (25.7%) with the high expression (positive cells> 60%) of P-gp. in 25 cases with P-gp positive, compared with 19 cases with P-gp negative. Of the cases with high-mi Of the cases with P-gp negative, the expression of CD44 showed a significant difference (P <0.05) in 22 cases with P-gp negative. Of the cases with clinical III - IV stage, the expression Of the cases with P-gp negative. Of the cases with lymph node metastasis, the CD44 expression showed a significant difference (P = 0.050) Of the cases of the patients’ age being more than 56 years, the expression of CD44 showed a significant difference (P <0.01) in 27 cases with P-gp negative. P-gp positive, compared with 12 cases with P-gp negative. When the P-gp and CD44 expression were positive, the clinical stage II and IV-IV stages showed a significant difference (P <0.05). : When the CD44 and P-gp both have the positive high expression, it will be signifi- cantly associated with the esophageal carcinoma progression and metastasis, so both were a positive expression in esophageal carcinoma, it might suggest a poor and unfavorable prognosis result.