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目的：通过检测GIST组织中Cortactin的表达情况，探讨其与GIST临床病理特征之间的关系，为预测该肿瘤的侵袭转移潜能提供理论依据。方法①采用免疫组化技术ELIVISION二步法检测42例GIST组织和10例正常胃组织中Cortactin蛋白表达情况；比较GIST组织中Cortactin蛋白的表达水平与其本身侵袭程度之间的关系；使用SPSS17.0软件对免疫组化结果进行统计学分析。结果 Cortactin在GIST组织中的表达明显高于正常胃组织(<0.001)，差异具有统计学意义。在GIST组织中Cortactin表达增高与GIST的肿瘤核分裂相、侵袭转移和高的NIH分级有关。Cortactin表达与GIST的NIH分级成正相关，即越高的NIH分级预示着Cortactin的表达越多(<0.01)。结论 Cortactin异常表达的程度可能与GIST的侵袭与转移有关，可能成为预测、评估GIST恶性潜能及肿瘤进展的重要指标，有望为临床治疗提供新的靶点。“,”Objective Through detecting the expression of Cortactin in gastrointestinal stromal tumor(GIST)tissues to disscuss the relationship between the expression and clinicopathological feature and provide theoretical basis to predict the potentiality of invasion and metastasis of the tumor.Methods ①The expression of Cortactin in 42 cases of GIST tissues and 10 cases of normal gastric tissues were detected by immunohistochemical ELIVISION two-step method. ② The relation of the expression level of Cortactin and the invasion degree of tumor was compared in GIST. The immunohistochemical results were statistical y analyzed by the software of SPSS17.0.Results The expression of Cortactin in GIST was significantly higher than that in normal gastric tissues ( <0.001), The result was of statistical significance. The expression rate and intensity of Cortactin was significantly correlated to the pathological mitotic figures,invasion and metastasis,high NIH stage of GIST. The upregulated expression of Cortactin had positive cor elation with clinical NIH stage of GIST, that is to say the more advanced clinical NIH stage cor esponding to the higher expression level of Cortactin ( <0.01). Conclusion The abnormal expression level of Cortactin may be related to invasion and metastasis of GIST,it may be an important biomarker for predicting and evaluating the malignant potentiality and progression of GIST, hopeful y providing a new target for clinical treatment.