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早已皆知胎盘可以视为免疫屏障,在保护胎儿免受母亲免疫系统攻击中起重要作用。但作者曾报导培养的鼠妊娠中期滋养层细胞虽带有Ⅰ类主要组织相容性抗原复合体(MHC)抗原,极易被特异性抗体和补体溶解,但不能被标准条件下培养的同种特异性细胞毒性 T 细胞(CTL)杀伤,另外还发现滋养层细胞也不被干扰素(IFN)激活的天然杀伤细胞或抗体依赖细胞介导细胞毒作用溶解,上述事实证实滋养层细胞抵抗细胞介导溶解能力是这
It has long been known that the placenta can be regarded as an immune barrier and plays an important role in protecting the fetus from attack by the mother’s immune system. However, it has been reported that in the mid-second trimester of pregnancy, trophoblast cells harbor the class I major histocompatibility antigen complex (MHC) antigen and are easily dissolved by specific antibodies and complement but not by the same species cultured under standard conditions Specific cytotoxic T-cell (CTL) killing in addition to the fact that trophoblast cells are also found not to be IFN-activated natural killer cells or antibody-dependent cell-mediated cytotoxicity has been shown to be cytotoxic Lead dissolving ability is this