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胃癌是严重危害人类健康最常见的恶性肿瘤,在我国占恶性肿瘤的23%.癌细胞浸润及淋巴结转移是胃癌术后复发和化疗失败的主要原因.因此,寻找胃癌浸润,转移的指标具有重要的临床意义.我们采用原位分子杂交技术、免疫组化 S-P法分别检测胃腺癌中端粒酶的活性及 nm23癌基因蛋白在胃癌组织中的表达,旨在探讨端粒酶、nm23与胃癌浸润、转移的关系.
Gastric cancer is the most common malignant tumor that seriously endangers human health and accounts for 23% of malignant tumors in our country.Cancer cell infiltration and lymph node metastasis are the main causes of postoperative recurrence and chemotherapy failure of gastric cancer.Therefore, it is important to find indicators of invasion and metastasis of gastric cancer We use in situ hybridization and immunohistochemical SP method to detect telomerase activity and nm23 oncogene protein expression in gastric cancer tissue in order to investigate the relationship between telomerase, nm23 and gastric cancer infiltration , The transfer of the relationship.