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目的 观察低分子肝素钠注射液联合奥扎格雷钠注射液治疗急性脑血栓的临床疗效及安全性.方法 将80例急性脑血栓患者随机分为对照组40例和试验组40例.对照组予以口服拉西地平2 mg,bid+口服格列吡嗪5 mg,bid.试验组在对照组治疗的基础上,予以皮下注射低分子肝素钠5000 U,qd+静脉滴注奥扎格雷钠60 mg,bid.2组患者均治疗4周.比较2组患者的临床疗效、神经功能缺损评分、血流动力学指标、致残率和复发率,以及药物不良反应的发生情况.结果 治疗后,试验组和对照组的总有效率分别为92.50％(37例/40例)和75.00％(30例/40例),差异有统计学意义(P＜0.05).治疗后,试验组和对照组的神经功能缺损评分分别为(14.30±1.30)和(16.12±1.71)分,全血黏度分别为(4.85±0.41)和(5.36±0.44) mPa·s,血浆黏度分别为(1.54±0.21)和(1.75±0.20)mPa·s,血细胞比容分别为(42.00±6.00)％和(49.00±3.00)％,纤维蛋白原分别为(3.72±0.34)和(3.95±0.37)g·L-1,差异均有统计学意义(均P＜0.05).2组患者的药物不良反应以乏力和口于为主,试验组和对照组的总药物不良反应率分别为7.50％和5.00％,差异无统计学意义(均P＞0.05).结论 低分子肝素钠注射液联合奥扎格雷钠注射液治疗急性脑血栓的临床疗效确切,可修复受损的神经细胞功能,改善预后,且不增加药物不良反应的发生率.“,”Objective To observe the clinical efficacy and safety of low molecular weight heparin sodium injection combined with ozagrel sodium injection in the treatment of acute cerebral thrombosis.Methods A total of 80 patients with acute cerebral thrombosis were randomly divided into control group and treatment group with 40 cases per group.Control group was given lacidipinc 2 mg bid,orally + glipizide 5 mg bid,orally.Treatment group was given low molecular heparin sodium 5000 U qd subcutaneous injection + ozagrel sodium 60 mg bid intravenous infusion,on the basis of control group.The clinical efficacy,the national institutes of health stroke score (NIHSS),hemodynamics indexes,morbidity and recurrence rates,and adverse drug reactions were compared between two groups.Results After treatment,the total effective rates in treatment and control groups were 92.50％ (37 cases/40 cases) and 75.00％ (30 cases/40 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:the scores of neural function defect scale were (14.30 ± 1.30) and (16.12 ± 1.71) points,whole blood viscosity were (4.85 ± 0.41) and (5.36 ± 0.44) mPa · s,plasma viscosity were (1.54 ± 0.21) and (1.75 ± 0.20) mPa· s,hematocrit were (42.00 ± 6.00)％ and (49.00 ± 3.00)％,fibrinogen were (3.72 ± 0.34) and (3.95 ± 0.37)g · L-1,the differences were statistically significant (all P ＜ 0.05).The adverse drug reactions in two groups were based on weak and dry mouth.The incidences of adverse drug reactions in treatment and control groups were 7.50％ and 5.00％ without significant difference (P ＞ 0.05).Conclusion Low molecular weight heparin sodium injection combined with ozagrel sodium injection has a definitive clinical efficacy,which can repair the damaged nerve cell function,improve the prognosis,without increasing the incidence of adverse drug reactions.