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目的了解应用司他夫定(d4T)、拉米夫定(3TC)、奈韦拉平(NVP)方案治疗艾滋病患者的效果。方法42例艾滋病患者用d4T、3TC、NVP方案治疗1年,所有患者于治疗前和治疗后每月随访1次,并分别在治疗0个月、6个月及12个月检测病毒载量、CD4+绝对计数和耐药情况。结果42例艾滋病患者治疗0个月、6个月、12月病毒载量平均值为5.00、2.54、2.03log10拷贝/ml,其中治疗6个月、12月后分别有24例、36例达到检测不到水平(<50拷贝/ml)。CD4+绝对计数治疗0个月、6个月、12月平均值分别为147、247、274个/mm3。42例患者在治疗后发现有1例患者对ABC、AZT、d4T、DDI有潜在低度耐药突变。结论艾滋病人规范使用抗病毒治疗效果满意。
Objective To investigate the effect of applying the stavudine (d4T), lamivudine (3TC) and nevirapine (NVP) regimens in the treatment of AIDS patients. Methods 42 patients with AIDS were treated with d4T, 3TC and NVP regimens for 1 year. All patients were followed up once a month before and after treatment. The viral load was tested at 0, 6 and 12 months respectively. CD4 + absolute count and drug resistance. Results The average viral load of 42 AIDS patients at 0 months, 6 months and 12 months was 5.00, 2.54 and 2.03 log10 copies / ml, of which 6 months and 12 months respectively, 24 cases and 36 cases were detected Less than level (<50 copies / ml). CD4 + absolute count treatment at 0 months, 6 months, 12 months averaged 147,247,274 / mm3.42 patients after treatment found that 1 patient with ABC, AZT, d4T, DDI potential low Drug-resistant mutation. Conclusion The standard of anti-virus treatment for AIDS patients is satisfactory.