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应用放射免疫法测定100例服用地高辛的心脏病患者及24例未服该药的正常人的血清地高辛浓度,结果是①3/4正常人测不出:②心脏病患者中,毒性反应组的血清地高辛浓度明显高于无毒性反应组;③地高辛毒性反应与病人肾功能不全及血钾浓度降低有关。作者认为,本法简便、快速、灵敏、特异,用它测定心脏病患者血中的地高辛浓度,可指导临床用药量,并建议以2毫微克/毫升作为国人毒性反应的界限。
Radioimmunoassay was used to determine the serum digoxin concentration in 100 patients with heart disease and 24 normal subjects who did not receive digoxin. As a result, 3/4 normal people could not measure: (1) in patients with heart disease, the toxicity The serum digoxin concentration of the reaction group was significantly higher than that of the non-toxic reaction group. (3) The toxicity of digoxin was related to the renal insufficiency and the decrease of serum potassium concentration. The authors believe that this method is simple, rapid, sensitive and specific, with its determination of the concentration of digoxin in the blood of patients with heart disease, can guide the clinical dosage, and recommended as 2 ng / ml as people’s toxicity limit.