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目的:了解阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆脂质代谢情况。方法:分别检测健康对照组、睡眠呼吸暂停综合征患者组甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A、载脂蛋白B、脂蛋白a、载脂蛋白E含量。进行统计学对比及分析。结果:睡眠呼吸暂停综合征患者的甘油三酯、总胆固醇、高密度脂蛋白、总胆固醇/高密度脂蛋白、载脂蛋白A、载脂蛋白B及载脂蛋白E与健康对照组比较有显著差异,且与其睡眠监测指标有明显相关。结论:OSAHS可导致血浆脂质代谢紊乱,与动脉粥样硬化发生及发展的存在重要的相关性,是独立于年龄、体重、饮食、遗传等原因的冠心病、高血压、脑卒中等心脑血管疾病的发病因素之一。因此,提高对OSAHS的警惕是非常重要的。
Objective: To understand the plasma lipid metabolism in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: The levels of triglyceride, total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, apolipoprotein a and apolipoprotein A in patients with sleep apnea syndrome were measured respectively in healthy control group, Protein E content. Statistical comparison and analysis. Results: Serum triglyceride, total cholesterol, high density lipoprotein, total cholesterol / high density lipoprotein, apolipoprotein A, apolipoprotein B and apolipoprotein E in patients with sleep apnea syndrome were significantly higher than those in healthy controls Differences, and with its sleep monitoring indicators were significantly related. Conclusion: OSAHS can lead to the disturbance of plasma lipid metabolism, and it has important correlation with the occurrence and development of atherosclerosis. It is an independent factor of cardiovascular disease such as coronary heart disease, hypertension and stroke independent of age, weight, diet and genetics One of the causes of vascular disease. Therefore, it is very important to improve the vigilance of OSAHS.