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Lainhart通过流行病学调查证实位于美国阿帕拉畿、伊利诺斯、印第安纳和犹他州等地的烟煤矿的煤矿工尘肺发病率有显著差异。Keenan等分析过西部弗吉尼亚州烟煤矿工肺组织和肺门淋巴结中铜、铁、铅和镍的含量比一般人高。Crable等也证实过该地烟煤矿工肺的铜、铅、镍含量高于一般人,且肺中的矿物含量比英国报导无烟煤矿工的高。他们又在同一地区的另一组烟煤矿工中发现,肺中铜、铁、镍和锌的含量高于一般人,而铅的含量低于一般人。Bergman等曾指出,单纯性尘肺患者
Lainhart confirmed through epidemiological investigations that there was a significant difference in the incidence of pneumoconiosis among coal miners in bituminous coal mines located in the United States, including Apolongu, Illinois, Indiana and Utah. Keenan et al. Analyzed the levels of copper, iron, lead and nickel in lung tissue and hilar lymph nodes of coal miners in western Virginia at a higher rate than the average person. Crable et al. Also confirmed that the miners of coal miners in the area had higher levels of copper, lead and nickel than the average person, and their mineral content in the lungs was higher than that of anthracite miners reported in the United Kingdom. Again, they found in another group of miners in the same area that copper, iron, nickel and zinc in the lungs were higher than the average person, while lead levels were lower than the average person. Bergman et al have pointed out that patients with simple pneumoconiosis