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IFN-γ可抑制弓形虫在肾脏等多种组织中的增殖,在免疫保护中具有重要作用,但组织的炎性病变程度与虫体的数量往往不成比例。近来有研究显示Toll样受体家族(TLRs)参与了肾脏抗感染的先天免疫机制;炎性病变的肾小管上皮细胞TLR2和TLR4mRNA合成明显增加;TLR2和髓样分化因子88(MyD8
IFN-γ inhibits the proliferation of Toxoplasma gondii in various tissues such as the kidney and plays an important role in immune protection. However, the degree of inflammatory lesions in tissues is often out of proportion to the number of parasites. Recent studies have shown that Toll-like receptor families (TLRs) are involved in the innate immune mechanism of kidney anti-infective; TLR2 and TLR4 mRNA synthesis is significantly increased in inflammatory lesions of tubular epithelial cells; TLR2 and myeloid differentiation factor 88 (MyD8