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为研究Ｅ－Ｃｄ在下咽癌标本中的表达及其临床意义，应用免疫组化ＳＡＢＣ方法，研究了６５例下咽癌手术标本。结果表明，随肿瘤临床分级的升高，Ｅ－Ｃｄ表达下降；随着肿瘤分化程度的降低，Ｅ－Ｃｄ表达下降；Ｅ－Ｃｄ的表达在淋巴结转移组明显低于无淋巴结转移组（Ｐ＜０．０５）。提示Ｅ－Ｃｄ在下咽癌中具有抑制肿瘤侵袭和转移的作用，可做为下咽癌分化差和癌细胞侵袭、转移的标记物。
In order to study the expression and clinical significance of E-Cd in hypopharyngeal carcinoma specimens, immunohistochemical SABC method was used to study 65 specimens of hypopharyngeal carcinoma. The results showed that with the increase of clinical grade of tumor, the expression of E-Cd decreased; as the degree of tumor differentiation decreased, the expression of E-Cd decreased; the expression of E-Cd was significantly lower in the lymph node metastasis group than in the group without lymph node metastasis (P< 0.05). It is suggested that E-Cd can inhibit tumor invasion and metastasis in hypopharyngeal carcinoma and can be used as a marker for poor differentiation of hypopharyngeal carcinoma and invasion and metastasis of cancer cells.