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目的:探讨肝硬化出血患者血小板参数与凝血因子动态变化的临床意义。方法:对54例肝硬化出血患者出血前第13、7、d的凝血酶原时间(PT)、血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、平均血小板分布宽度(PDW)、大血小板比率(P-LCR)进行动态检测,同时将患者初入院的相应指标作为对照组,并进行统计学比较。结果:PLT与对照组比较,肝硬化出血患者出血前1 d3、d、7 d具有明显下降的趋势,PDW、P-LCR、PT则明显升高。PCT、MPV无明显差异。结论:肝硬化患者由于血小板数量减少、血小板功能缺陷及凝血功能障碍易合并消化道出血,动态监测其综合测定值有助于作为肝硬化患者出血倾向的预警,指导早期防治。
Objective: To investigate the clinical significance of platelet parameters and coagulation factors in patients with cirrhosis hemorrhage. Methods: The changes of PT, PLT, PCT, MPV and mean platelet distribution on the 13th, 7th day before hemorrhage in 54 cirrhotic patients with hemorrhage were analyzed. (PDW) and large platelet ratio (P-LCR). Meanwhile, the corresponding indexes of early hospital admission were taken as control group, and statistical comparison was made. Results: Compared with the control group, the levels of PDW, P-LCR and PT in the patients with cirrhosis hemorrhage were significantly decreased on the 1st, 3rd, and 7th day before hemorrhage. PCT, MPV no significant difference. Conclusion: Due to the decrease of platelet count, platelet function defect and coagulation dysfunction, patients with liver cirrhosis are likely to have gastrointestinal hemorrhage. The dynamic monitoring of the integrated value of cirrhosis patients is helpful to predict the bleeding tendency of cirrhotic patients and guide the early prevention and treatment.