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十二指肠的硷性液体向胃返流本来经常发生。但过度的十二指肠胃返流(DGR)则可导至胃窦炎,胃粘膜肠化和上腹痛、恶心呕吐等症状。病理性的DGR时血清胃泌素升高,可引起胃窦硷化和壁细胞的损害。胃液量和胆酸成分的测定,胃镜活检,上消化道造影等均不能确定病人患有过度十二指肠胃返流。因为DGR的间断发作特性不可能在一个体外实验环境下短时间内进行独立的定量测定和刺激试验。本文作者根据胃的生理节奏在24小时内连续测定胃pH,使DGR病人得到确诊。此法与加用缩胆囊素刺激的异丙氟磷亚氨基乙烯乙酸(DISIDA)扫描法进行对比。
Duodenal alkaline fluid reflux to the stomach had always occurred. However, excessive duodenal reflux (DGR) can lead to antral gastritis, gastric mucosal intestinal metaplasia and pain, nausea and vomiting and other symptoms. Pathological DGR serum gastrin, can cause gastric antrum and parietal cells damage. Determination of gastric juice and bile acid composition, endoscopic biopsy, upper gastrointestinal angiography, etc. can not determine the patient suffering from excessive duodenal reflux. Because of the intermittent nature of DGR it is not possible to conduct independent quantitation and stimulation assays in a short period of time in an in vitro experimental setting. The authors measured the gastric pH continuously for 24 hours based on the physiologic rhythm of the stomach, confirming the diagnosis of DGR. This method was compared with cholecystokinin-isopropafluoro-iminoethylacetic acid (DISIDA) scanning.