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目的研究多巴胺转运蛋白 (DAT)放射性配体12 3I-、131I- β -CIT在正常恒河猴体内的分布 ,探讨其临床应用前景。 方法于正常恒河猴肘静脉处弹丸注射12 3I- β-CIT(9mCi)或131I- β-CIT(10mCi)后 ,运用单光子发射计算机断层扫描仪 (SPECT)连续动态进行全身和头部断层扫描 ,计算各时间点感兴趣区 (ROI)的放射性计数。结果不同时间的断层扫描显示注射后 2 4h ,在纹状体部位的放射性浓集最清晰 ,纹状体 /额叶比值 1.78,左、右侧纹状体及与同侧额叶、颞叶和枕叶的比值基本相同 ;全身动态扫描显示 β -CIT主要分布在消化道 (胆囊和空、回肠 )。结论在脑内 β-CIT主要分布在纹状体 ,注射后 2 4h是脑断层扫描的最佳时间点 ;12 3I- β -CITSPECT在体显像可用于检测纹状体DAT的功能或密度。
Objective To investigate the distribution of dopamine transporter (DAT) radioligand 12 3I-, 131I- β -CIT in normal rhesus monkeys and to explore their clinical application prospects. Methods The whole body and the head of the rhesus monkey were continuously and dynamically dissected by single photon emission computerized tomography (SPECT) after injection of 12 3I-β-CIT (9mCi) or 131I-β-CIT (10mCi) Scan and calculate the radioactive count of ROI at each time point. Results The different time of tomography showed that the radioactive concentration in the striatum was the clearest at 14 hrs after injection, with striatum / frontal ratio 1.78. The left and right striatum, The ratio of occipital lobe was basically the same; whole body dynamic scan showed that β -CIT mainly distributed in the digestive tract (gallbladder and empty, ileum). Conclusion β-CIT in the brain is mainly distributed in the striatum, and the optimal time point for brain CT scan is 24 hours after injection. The in vivo imaging of 123I-β -CITSPECT can be used to detect the function or density of striatum DAT.