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目的探讨急性心肌梗死（ＡＭＩ）病人血浆补体活化片段浓度的动态变化及意义。②方法采用酶联免疫吸附法（ＥＬＩＳＡ），检测了６７例ＡＭＩ病人发病第１，４，７天时和３８例健康人、４２例陈旧性心肌梗死（ＯＭＩ）病人血浆补体活化片段（ｓＣ５ｂ－９）浓度的变化。③结果ＡＭＩ病人ｓＣ５ｂ－９浓度明显增高，与对照组和ＯＭＩ病人比较差异有极显著性（Ｆ＝１８．６７３，ｑ＝８．４２３～１６．８５１，Ｐ＜０．００１）。发病第１，４，７天，ｓＣ５ｂ－９浓度逐渐降低，差异有极显著性（Ｆ＝１４．６２８，ｑ＝６．２７５～１４．１６２，Ｐ＜０．００１）。病死者和伴有室性心律失常者ｓＣ５ｂ－９增高较存活者和无室性心律失常者更明显（ｔ＝１３．６４９，８．３９５，Ｐ＜０．００１）。④结论补体活化片段浓度的动态变化参与了ＡＭＩ的发生和发展，且与病情严重程度和预后有密切关系。
Objective To investigate the dynamic changes of plasma complement activation fragment in patients with acute myocardial infarction (AMI) and its significance. Methods The enzyme linked immunosorbent assay (ELISA) was used to detect the plasma level of complement (sC5b-9) in patients with AMI at day 1, day 4, day 7, and 38 healthy subjects, 42 patients with old myocardial infarction (OMI) ) Concentration changes. Results The concentration of sC5b-9 in AMI patients was significantly higher than that in control group and OMI patients (F = 18.673, q = 8.423-16.851, P <0.001). On the 1st, 4th and 7th days, the concentration of sC5b-9 gradually decreased, with a significant difference (F = 14.628, q = 6.275-14.1462, P <0.001). Sc5b-9 was significantly higher in the deceased and those with ventricular arrhythmias than in those with or without ventricular arrhythmias (t = 13.649, 8.395, P <0.001). ④ Conclusion The dynamic changes of complement activation fragment concentration involved in the occurrence and development of AMI, and with the severity and prognosis are closely related.