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目的 研究糖尿病并发症和无并发症血浆血栓调节蛋白 (PTM)水平及其临床意义。方法 用 EL ISA法检测 PTM的水平。结果 糖尿病并发症组 PTM(38.14± 12 .89) μg/ L显著高于无并发症组 (2 2 .11± 6 .5 8) μg/ L,P <0 .0 1,无并发症组与健康对照组 (2 0 .2 3± 7.5 4) μg/ L 几乎处于同一水平。并发症中 ,微血管病变组 PTM水平 (43.5 1± 13.2 8)μg/ L最高 ,明显高于大血管病变组 (31.89± 8.2 5 )μg/ L ,P <0 .0 1,且 PTM水平随 2 4h尿白蛋白排泄量增加而升高。相关分析提示 PTM与血糖 (r=0 .0 36 2 )、胆固醇 (r=- 0 .0 2 2 9)、甘油三酯 (r =0 .0 32 5 )、血浆纤维蛋白原 (r=0 .2 112 )、纤维蛋白降解产物 (r =- 0 .0 2 2 9)和年龄因素 (r=0 .2 34 1)均无相关性。结论 测定 PTM可以评估糖尿病血管内皮细胞的损伤及其程度和判断血管并发症的有无及其类型
Objective To study the clinical significance and complications of diabetic thrombomodulin (PTM) and its complications. Methods ELISA method was used to detect the level of PTM. Results The diabetic group had significantly higher PTM (38.14 ± 12.89) μg / L than those without complications (21.2 ± 6.18 μg / L, P <0.01), with no complication The healthy control group (2.023 ± 7.54) μg / L was almost at the same level. In the complication, the level of PTM in microvascular group was the highest (43.5 1 ± 13.2 8) μg / L, which was significantly higher than that in macrovascular group (31.89 ± 8.2 5) μg / L, P <0.01, 4h urinary albumin excretion increased and increased. Correlation analysis showed that PTM was positively correlated with plasma glucose (r = 0.362), cholesterol (r = -0.0229), triglyceride (r = 0.3252), plasma fibrinogen .2 112), fibrin degradation products (r = -0.0229) and age factors (r = 0.234 1) were not related. Conclusions PTM can be used to assess the extent and severity of diabetic vascular endothelial cells and to determine the type and type of vascular complications