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[目的]探讨周围型非小细胞肺癌CT征象与表皮生长因子受体(EGFR)表达的关系。[方法]采用免疫组织化学二步法检测72例经病理证实的周围型非小细胞肺癌(腺癌51例,鳞癌21例)组织中EGFR的表达情况,并分析其与CT征象的关系。[结果]72例周围型非小细胞肺癌中EGFR阳性率52.78%(38/72)。EGFR表达与CT征象中的深分叶征、棘突征、纵隔淋巴结转移及CT增强阳性有关(P均<0.05)。[结论]非小细胞肺癌中EGFR高表达与CT征象的深分叶征、棘突征、纵隔淋巴结转移及CT增强阳性有关。
[Objective] To investigate the relationship between CT signs and the expression of epidermal growth factor receptor (EGFR) in peripheral non-small cell lung cancer. [Method] The expression of EGFR in 72 cases of peripheral non-small cell lung cancer (51 cases of adenocarcinoma and 21 cases of squamous cell carcinoma) confirmed by pathology was detected by immunohistochemical two-step method and its relationship with CT signs was analyzed. [Results] The positive rate of EGFR in 72 cases of peripheral non-small cell lung cancer was 52.78% (38/72). The expression of EGFR was correlated with deep lobulation sign, spinous process, mediastinal lymph node metastasis and CT enhancement (all P <0.05). [Conclusion] The high expression of EGFR in non-small cell lung cancer is associated with deep lobulation sign of CT, spondylolisthesis, mediastinal lymph node metastasis and positive CT enhancement.