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应用免疫组化SP法和计算机图象分析系统对bcl-2基因蛋白在41例鼻咽癌中的表达进行定性和定量分析,结果显示bcl-2基因在鼻咽癌中出现异常高表达(阳性率为82.9%),bcl-2表达率和表达量与鼻咽癌组织学分级及颈淋巴结转移无显著性关系(P>0.05)。提示bcl-2基因对鼻咽上皮的良恶性诊断有重要的临床参考价值。
Immunohistochemical SP method and computer image analysis system were used to qualitatively and quantitatively analyze the expression of bcl-2 gene protein in 41 cases of nasopharyngeal carcinoma. The results showed that bcl-2 gene was abnormally expressed in nasopharyngeal carcinoma (positive The rate was 82.9%). The expression and expression of bcl-2 had no significant relationship with the histological grade and cervical lymph node metastasis of nasopharyngeal carcinoma (P>0.05). It is suggested that bcl-2 gene has important clinical reference value for the diagnosis of benign and malignant nasopharyngeal epithelium.