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目的探讨表皮生长因子(EGF)与妊娠期糖尿病(GDM)发病的关系。方法采用放射免疫法测定30例GDM病人(GDM组)及30例正常孕妇(对照组)母体血清及脐血中EGF的水平。采用免疫组织化学法测定葡萄糖及胰岛素刺激前后两组胎盘组织中EGF受体(EGFR)的表达。结果 GDM组EGF、EGFR水平均明显高于对照组(t=8.79～55.88,P<0.01);胰岛素及葡萄糖刺激后两组EGFR表达水平均明显增加(t=85.02～112.28,P<0.01)。结论 EGF与GDM的发病可能无明显关系,而与其合并巨大儿有关,其受体水平升高可能是高糖血症、高胰岛素血症刺激的结果。
Objective To investigate the relationship between epidermal growth factor (EGF) and gestational diabetes mellitus (GDM). Methods The levels of EGF in maternal serum and umbilical cord blood of 30 GDM patients and 30 normal pregnant women (control group) were determined by radioimmunoassay. Immunohistochemistry was used to detect the expression of EGFR in placenta of both groups before and after glucose and insulin stimulation. Results The levels of EGF and EGFR in GDM group were significantly higher than those in control group (t = 8.79-55.88, P <0.01). The levels of EGFR in both groups were significantly increased after insulin and glucose stimulation (t = 85.02-112.28, P <0.01). Conclusion The incidence of EGF and GDM may not have a clear relationship, but with its giant macrosomia, its receptor levels may be hyperglycaemia, hyperinsulinemia stimulation results.